Semantic Coherence: FYCOMPA (Catalyst Pharmaceuticals) – Signal Evidence & AI Readability

[H1]
FYCOMPA®
(perampanel)
is
still
available.
If
you
received
generic
perampanel
instead
of
FYCOMPA
but
didn't
want
this
change,
here's
what
you
should
know:

What
is
FYCOMPA
(perampanel)?

FYCOMPA
is
a
prescription
medicine
used
alone
or
with
other
medicines
to
treat
partial-onset
seizures
with
or
without
secondarily
generalized
seizures
in
people
with
epilepsy
aged
4
and
older
and
with
other
medicines
to
treat
primary
generalized
tonic-clonic
seizures
in
people
with
epilepsy
aged
12
and
older.

Catalyst is committed to supporting you every step of the way. For details and to explore available resources, please visit the
Tools &
Support page.

Could
FYCOMPA
help
control
my
seizures?

In
clinical
trials,
some
patients
taking
FYCOMPA
experienced
fewer
seizures.Individual
results
may
vary.

Ask
your
doctor
if
FYCOMPA
is
right
for
you.

If
you’ve
been
living
with
epilepsy
for
a
while,
it
might
feel
hard
to
imagine
what
life
with
fewer
seizures
could
be
like.

FYCOMPA
may
be
able
to
help.

FYCOMPA
is
approved
to
treat
partial-onset
seizures
with
or
without
secondarily
generalized
seizures
in
people
with
epilepsy
who
are
4
years
of
age
and
older
and
with
other
medicines
to
treat
primary
generalized
tonic-clonic
seizures
in
people
with
epilepsy
who
are
12
years
of
age
and
older.

Find
Out
How

Stay
up
to
date
with
FYCOMPA

400,000
people
worldwide
have
been
prescribed
FYCOMPA,
and
the
community
continues
to
grow!*,†

*Worldwide
figure
through
March
2021.
Nearly
50,000
patients
prescribed
FYCOMPA
in
the
United
States
†Across
all
indications

Get access to additional information:

“
Epilepsy does not define me.
”
Watch
real
FYCOMPA
patient
stories

Catalyst is committed to supporting you every step of the way. For details and to explore available resources, please visit the
Tools & Support page. We appreciate the trust that you continue to place in FYCOMPA.

What
if
I
miss
a
dose?

If
you
happen
to
miss
a
dose
of
FYCOMPA,
just
take
your
next
day’s
dose
as
you
normally
would
to
get
back
on
track—don’t
double
up.
If
you
miss
taking
FYCOMPA
for
more
than
one
day,
call
your
doctor
to
discuss
next
steps.

Learn
more
about
taking
FYCOMPA

Understand
and
help
manage
side
effects

FYCOMPA
(perampanel)
can
cause
side
effects

Let
your
doctor
know
if
you
have
side
effects

Some
side
effects
may
be
more
frequent
at
higher
doses
and/or
while
your
body
is
getting
used
to
the
medication

If
you
experience
a
side
effect,
your
doctor
may
step
down
your
dose—or
even
take
you
off
FYCOMPA

Don’t
stop
taking
FYCOMPA
on
your
own—you’ll
need
to
follow
your
doctor’s
instructions

Pay
attention
to
your
mood,
especially
as
you’re
getting
used
to
taking
FYCOMPA

It’s
important
for
your
doctor
to
know
if
you
have
any
unusual
changes
in
behavior
or
mood

Call
your
doctor
right
away
if
you
are
having
mental
problems,
including
aggressive
or
suicidal
thoughts

Learn
more

“
Epilepsy
does
not
define
me.
”

Watch
real
FYCOMPA
patient
stories

Get
important
FYCOMPA
updates

400,000
people
worldwide
have
been
prescribed
FYCOMPA,
and
the
community
continues
to
grow!‡,§
Stay
current
when
it
comes
to
the
latest
FYCOMPA
information
and
resources.

‡Worldwide
figure
through
March
2021.
Nearly
50,000
patients
prescribed
FYCOMPA
in
the
United
States.§Across
all
indications

What is FYCOMPA
(perampanel)?

FYCOMPA is a
prescription medicine
used alone or with other
medicines to treat
partial-onset seizures
with or without
secondarily generalized
seizures in people with
epilepsy aged 4 and
older and with other
medicines to treat
primary generalized
tonic-clonic seizures in
people with epilepsy
aged 12 and older.

IMPORTANT SAFETY
INFORMATION

FYCOMPA may cause
mental (psychiatric)
problems, including:

new or worse
aggressive behavior
(including homicidal
behavior),
hostility, anger,
anxiety, or
irritability; being
suspicious or
distrustful
(believing things
that are not true);
seeing objects or
hearing things that
are not there;
confusion;
difficulty with
memory; other
unusual or extreme
changes in behavior
or mood. Tell your
healthcare provider
right away if you
have any new or
worsening mental
problems while
taking FYCOMPA.

What is FYCOMPA
(perampanel)?

FYCOMPA is a
prescription
medicine used alone
or with other
medicines to treat
partial-onset
seizures with or
without secondarily
generalized seizures
in people with
epilepsy aged 4 and
older and with other
medicines to treat
primary generalized
tonic-clonic
seizures in people
with epilepsy aged
12 and older.

Like other antiepileptic
drugs, FYCOMPA may cause
suicidal thoughts or
actions in a very small
number of people, about
1 in 500. Call your
healthcare provider
right away if you have
any of these symptoms,
especially if they are
new, worse, or worry
you:

thoughts about suicide
or dying; new or worse
depression; feeling
agitated or restless;
trouble sleeping
(insomnia); acting
aggressive; being angry,
or violent; an extreme
increase in activity and
talking (mania); attempt
to commit suicide; new
or worse anxiety; panic
attacks; new or worse
irritability; acting on
dangerous impulses;
other unusual changes in
behavior or mood.
Suicidal thoughts or
actions can be caused by
things other than
medicines. If you have
suicidal thoughts or
actions, your healthcare
provider may check for
other causes.

Pay attention to any
changes especially
sudden changes in mood,
behaviors, thoughts, or
feelings and keep all
follow-up visits with
your healthcare provider
as scheduled. Call your
healthcare provider
between visits as
needed, especially if
you are worried about
symptoms.

Do not stop FYCOMPA
without first talking
with your healthcare
provider.

Stopping suddenly can
cause serious problems
and can cause you to
have seizures more
often.

Before taking FYCOMPA,
tell your healthcare
provider about all of
your medical conditions,
including if you:

have or have had
depression, mood
problems, aggressive or
hostile behavior (for
example, homicidal
behavior), suicidal
thoughts or behavior, or
other psychiatric
problems; have liver or
kidney problems; drink
alcohol; have abused
prescription medicines,
street drugs, or alcohol
in the past; are
pregnant or plan to
become pregnant. It is
not known if FYCOMPA
will harm your unborn
baby. If you become
pregnant while taking
FYCOMPA, talk to your
healthcare provider
about registering with
the North American
Antiepileptic Drug
Pregnancy Registry
(1-888-233-2334)(1-888-233-2334); are breastfeeding or
plan to breastfeed. Talk
to your healthcare
provider about the best
way to feed your baby if
you take FYCOMPA and to
decide if you will take
FYCOMPA or breastfeed.
You should not do both.

Tell your healthcare
provider about all the
medicines you take,

including prescription
and over-the-counter
medicines, vitamins, and
herbal supplements.
Taking FYCOMPA with
certain other medicines
can cause side effects
or reduce either drug’s
benefit. These medicines
include: birth control,
carbamazepine,
phenytoin,
oxcarbazepine, rifampin,
and St. John’s Wort.

What should I avoid
while taking FYCOMPA?

Do not drive, operate
heavy machinery, or do
other dangerous
activities until you
know how FYCOMPA affects
you. FYCOMPA may make
you dizzy, sleepy, or
tired. Do not drink
alcohol or take other
medicines that make you
sleepy or dizzy until
you talk to your
healthcare provider.
FYCOMPA taken with
alcohol or medicines
that cause sleepiness or
dizziness may make your
sleepiness or dizziness
worse. FYCOMPA when
taken with alcohol may
also make your mood
worse, increase anger,
confusion, and
depression.

FYCOMPA may cause other
serious side effects,
including: Dizziness,
vertigo (sense of
spinning), and problems
walking normally.

You may have problems
walking normally if you
are unsteady because you
feel dizzy. These
symptoms can increase
when your dose of
FYCOMPA is increased.
Your risk of feeling
dizzy and having
problems walking
normally may be higher
if you are
elderly;
Sleepiness and
tiredness; Increased
risk of
falls.
Taking FYCOMPA can
increase your chance of
falling. These falls can
cause serious injuries.
Your risk of falling may
be higher if you are
elderly;
A serious allergic
reaction that may
affect your skin or
other parts of your
body such as your
liver, kidneys,
heart, or blood
cells.
This allergic reaction
can be life-threatening
and can cause death.
Call your healthcare
provider right away if
you have: a skin rash,
hives; fever or swollen
glands that do not go
away; swelling of your
face; shortness of
breath; swelling of the
legs; yellowing of the
skin or whites of the
eyes; or dark urine

The most common side
effects of FYCOMPA
include:

dizziness; sleepiness;
tiredness; irritability;
falls; nausea and
vomiting; weight gain;
vertigo (sense of
spinning); problems
walking normally;
problems with muscle
coordination; headache;
bruising; abdominal
pain; anxiety

FYCOMPA is a controlled
substance (CIII) because
it can be abused or lead
to drug dependence. Keep
FYCOMPA in a safe place
to protect it from theft
and never give it to
anyone else because it
may harm them. Selling
or giving away FYCOMPA
is against the law.

You are encouraged to
report negative side
effects of prescription
drugs to the FDA. Visit
www.fda.gov/medwatch
or call
1-800-FDA-10881-800-FDA-1088.

Prescribing
Information
and
Medication Guide
for FYCOMPA.

[H1] Tools & Support

[H2] Welcome to your road trip with FYCOMPA!

True to any road trip, we need to map out
our journey and figure out places to stop
along the way.
Get in and let’s get
started!

[H2] Your journey starts here

Let’s get to know your seizure
type(s) to figure out the best road trip
for you!

Know your seizure type

SEIZURES WITH
CONVULSIONS

Partial-onset
seizures that
secondarily
generalize

Primary
generalized
tonic-clonic
seizures

Start on one
side of the
brain and spread
to the other

Start on both
sides of the
brain at the
same time

Usually last 1 to 2 minutes
Happen without warning
Stiffening or jerking
movements can be strong or
forceful

Loss of consciousness,
falling to the floor

Breathing can be temporarily
impaired

No memory of the event
happening

SEIZURES WITHOUT
CONVULSIONS

Partial-onset
seizures that do
not
secondarily
generalize

Happen in one
part of the
brain

Usually last less than 2
minutes

Experiences can vary
depending on where in the
brain the seizure occurs

Stiffening or jerking
movements

Changes in smell, taste, and
hearing

Strange sensations in the
body can occur
or affect how
people think or experience
events

Sometimes memory is lost

[H2] A guide to help you find your way

It can be easy to forget what questions you
may have or what you want to say to your
doctor. This guide is a way to make sure you
have all your points ready for your next
appointment.
Download the discussion guide for your
next doctor’s visit.

Discussion guide

[H2] Make time for rest stops

Don’t forget to take time to
recharge on your journey. FYCOMPA has
resources for caregivers of those with
epilepsy, including help for pediatric
patients.

Tips to help you keep
going:

Reach out to others for support.
When people offer help, accept!

Get in touch with other caregivers
online so you can learn from each
other

Don’t forget to care for
yourself! Stay healthy with
exercise, the right food, and enough
sleep*

Avoid stressful situations when you
can and take time for yourself
(without feeling guilty about it)

*Talk with your healthcare provider before
starting a new diet or exercise routine.†Used alone or with other medicines to treat
partial-onset seizures with or without
secondarily generalized seizures.

[H2]
Hear from others who have gone the same
route

Your browser does not support the video
tag.

Leslie talks about how epilepsy has
impacted the relationships in her life

Your browser does not support the video
tag.

Nick talks about being diagnosed
with epilepsy at a young age

Your browser does not support the video
tag.

Shantia tells her story about
finding the right treatment

[H2] What to look forward to on the way

[H3] Learn what to expect with FYCOMPA.

The path to finding the right
antiseizure medication might seem like a
faraway destination, but it could be
closer than you think! Here’s how
FYCOMPA is thought to work:

FYCOMPA works differently from other
antiseizure drugs. It is the first
and only antiseizure medication that
targets a specific receptor in the
brain called “AMPA.” This receptor
plays a role in allowing seizures to
happen. As with many other seizure
medications, the way FYCOMPA works
is not fully understood.

[H2] Navigating new territory

Adjusting to your treatment can
take time, here are some things to
look out for to help you avoid
potential roadblocks.

Record your triggers and keep your
doctor up to date on side effects you
may be experiencing.

[H3]
Common seizure triggers: Do any of
these affect you?
Click on the ones you know
about—and keep an eye on the
others.
It isn’t always easy, but you
may be able to avoid some triggers.

CERTAIN TIMES
Specific times of day or
night

Times of fever or illness

In women, around the
menstrual cycle or other
hormonal changes

CERTAIN STIMULI OR SUBSTANCES
Stress

Drinking alcohol

Flashing bright lights or
patterns

Specific foods or products

Too much caffeine

PHYSICAL HEALTH AND CARE
Not taking medication

Not eating well—low blood
sugar

Not getting enough sleep

Make sure your doctor and care team
are always up to date about your
triggers as well!

[H2] Once you’ve hit the open road

Your journey is just beginning, but
you’re not alone!

Finding your stable dosage is another
step closer to seizure control!‡
Keep taking FYCOMPA as prescribed, stay
connected with your doctor’s
office
and let them know if:

You experience a seizure (it might
be time for a dose adjustment)
You have side effects
You miss a dose more than once
You have questions

‡In clinical trials,
some patients taking FYCOMPA experienced
fewer seizures. Individual results may
vary.

Please read the
Medication Guide, including the information about
serious mental (psychiatric) problems.
The Medication Guide does not take the
place of talking with your healthcare
provider about your condition or your
treatment.

[H2] Find your travel buddies

Remember your goals from earlier in
your journey? Go back and celebrate
your milestones with a family
member, partner, or close
friend!

REFERENCE: 1. FYCOMPA US
Prescribing Information. Coral Gables, FL:
Catalyst Pharmaceuticals, Inc.

What is FYCOMPA
(perampanel)?

FYCOMPA is a prescription
medicine used alone or with
other medicines to treat
partial-onset seizures with
or without secondarily
generalized seizures in
people with epilepsy aged 4
and older and with other
medicines to treat primary
generalized tonic-clonic
seizures in people with
epilepsy aged 12 and older.

IMPORTANT SAFETY INFORMATION

FYCOMPA may cause mental
(psychiatric) problems,
including:

new or worse aggressive
behavior (including
homicidal behavior),
hostility, anger,
anxiety, or
irritability; being
suspicious or
distrustful (believing
things that are not
true); seeing objects or
hearing things that are
not there; confusion;
difficulty with memory;
other unusual or extreme
changes in behavior or
mood. Tell your
healthcare provider
right away if you have
any new or worsening
mental problems while
taking FYCOMPA.

What is FYCOMPA
(perampanel)?

FYCOMPA is a
prescription medicine
used alone or with other
medicines to treat
partial-onset seizures
with or without
secondarily generalized
seizures in people with
epilepsy aged 4 and
older and with other
medicines to treat
primary generalized
tonic-clonic seizures in
people with epilepsy
aged 12 and older.

Like other antiepileptic
drugs, FYCOMPA may cause
suicidal thoughts or actions
in a very small number of
people, about 1 in 500. Call
your healthcare provider
right away if you have any
of these symptoms,
especially if they are new,
worse, or worry you:

thoughts about suicide or
dying; new or worse
depression; feeling agitated
or restless; trouble
sleeping (insomnia); acting
aggressive; being angry, or
violent; an extreme increase
in activity and talking
(mania); attempt to commit
suicide; new or worse
anxiety; panic attacks; new
or worse irritability;
acting on dangerous
impulses; other unusual
changes in behavior or mood.
Suicidal thoughts or actions
can be caused by things
other than medicines. If you
have suicidal thoughts or
actions, your healthcare
provider may check for other
causes.

Pay attention to any changes
especially sudden changes in
mood, behaviors, thoughts,
or feelings and keep all
follow-up visits with your
healthcare provider as
scheduled. Call your
healthcare provider between
visits as needed, especially
if you are worried about
symptoms.

Do not stop FYCOMPA without
first talking with your
healthcare provider.

Stopping suddenly can cause
serious problems and can
cause you to have seizures
more often.

Before taking FYCOMPA, tell
your healthcare provider
about all of your medical
conditions, including if
you:

have or have had depression,
mood problems, aggressive or
hostile behavior (for
example, homicidal
behavior), suicidal thoughts
or behavior, or other
psychiatric problems; have
liver or kidney problems;
drink alcohol; have abused
prescription medicines,
street drugs, or alcohol in
the past; are pregnant or
plan to become pregnant. It
is not known if FYCOMPA will
harm your unborn baby. If
you become pregnant while
taking FYCOMPA, talk to your
healthcare provider about
registering with the North
American Antiepileptic Drug
Pregnancy Registry
(1-888-233-2334)(1-888-233-2334); are breastfeeding or plan
to breastfeed. Talk to your
healthcare provider about
the best way to feed your
baby if you take FYCOMPA and
to decide if you will take
FYCOMPA or breastfeed. You
should not do both.

Tell your healthcare
provider about all the
medicines you take,

including prescription and
over-the-counter medicines,
vitamins, and herbal
supplements. Taking FYCOMPA
with certain other medicines
can cause side effects or
reduce either drug’s
benefit. These medicines
include: birth control,
carbamazepine, phenytoin,
oxcarbazepine, rifampin, and
St. John’s Wort.

What should I avoid while
taking FYCOMPA?

Do not drive, operate heavy
machinery, or do other
dangerous activities until
you know how FYCOMPA affects
you. FYCOMPA may make you
dizzy, sleepy, or tired. Do
not drink alcohol or take
other medicines that make
you sleepy or dizzy until
you talk to your healthcare
provider. FYCOMPA taken with
alcohol or medicines that
cause sleepiness or
dizziness may make your
sleepiness or dizziness
worse. FYCOMPA when taken
with alcohol may also make
your mood worse, increase
anger, confusion, and
depression.

FYCOMPA may cause other
serious side effects,
including: Dizziness,
vertigo (sense of spinning),
and problems walking
normally.

You may have problems
walking normally if you are
unsteady because you feel
dizzy. These symptoms can
increase when your dose of
FYCOMPA is increased. Your
risk of feeling dizzy and
having problems walking
normally may be higher if
you are elderly;
Sleepiness and
tiredness; Increased
risk of falls.
Taking FYCOMPA can increase
your chance of falling.
These falls can cause
serious injuries. Your risk
of falling may be higher if
you are elderly;
A serious allergic
reaction that may affect
your skin or other parts
of your body such as
your liver, kidneys,
heart, or blood cells.
This allergic reaction can
be life-threatening and can
cause death. Call your
healthcare provider right
away if you have: a skin
rash, hives; fever or
swollen glands that do not
go away; swelling of your
face; shortness of breath;
swelling of the legs;
yellowing of the skin or
whites of the eyes; or dark
urine

The most common side effects
of FYCOMPA include:

dizziness; sleepiness;
tiredness; irritability;
falls; nausea and vomiting;
weight gain; vertigo (sense
of spinning); problems
walking normally; problems
with muscle coordination;
headache; bruising;
abdominal pain; anxiety

FYCOMPA is a controlled
substance (CIII) because it
can be abused or lead to
drug dependence. Keep
FYCOMPA in a safe place to
protect it from theft and
never give it to anyone else
because it may harm them.
Selling or giving away
FYCOMPA is against the law.

You are encouraged to report
negative side effects of
prescription drugs to the
FDA. Visit
www.fda.gov/medwatch
or call
1-800-FDA-1088.

Prescribing
Information
and
Medication Guide
for FYCOMPA.

FYCOMPA is a
prescription
medicine
used alone
or with
other
medicines to
treat
partial-onset
seizures
with or
without
secondarily
generalized
seizures in
people with
epilepsy
aged 4 and
older and
with other
medicines to
treat
primary
generalized
tonic-clonic
seizures in
people with
epilepsy
aged 12 and
older.

[H2]
Convulsive seizure
control is
possible.*

Ask your doctor
if FYCOMPA could
help control
your seizures.

*In
clinical trials,
some patients
taking FYCOMPA
experienced
fewer seizures.
Individual
results may
vary.

[H1]
What are
breakthrough
seizures?
Some people
take
medication
but still
have
seizures.
When this
happens,
they are
called
"breakthrough
seizures".

Not sure if
your
seizures are
under
control?
Take the
Seizure
Control
Quiz

[H2]
Leslie
and
her
husband
talk
about
life
and
relationships
before
and
after
taking
FYCOMPA
to
treat
her
seizures.

Watch
Leslie's
FYCOMPA
story

[H2]
Get important FYCOMPA updates
400,000 people worldwide have been prescribed
FYCOMPA, and the community continues to grow!‡§
Stay current when it comes to the latest FYCOMPA
information and resources.

‡Worldwide
figure
through
March
2021.
Nearly
50,000
patients
prescribed
FYCOMPA
in
the
United
States.§Across
all
indications

What is FYCOMPA
(perampanel)?

FYCOMPA is a
prescription medicine
used alone or with other
medicines to treat
partial-onset seizures
with or without
secondarily generalized
seizures in people with
epilepsy aged 4 and
older and with other
medicines to treat
primary generalized
tonic-clonic seizures in
people with epilepsy
aged 12 and older.

IMPORTANT SAFETY
INFORMATION

FYCOMPA may cause
mental (psychiatric)
problems, including:

new or worse
aggressive behavior
(including homicidal
behavior),
hostility, anger,
anxiety, or
irritability; being
suspicious or
distrustful
(believing things
that are not true);
seeing objects or
hearing things that
are not there;
confusion;
difficulty with
memory; other
unusual or extreme
changes in behavior
or mood. Tell your
healthcare provider
right away if you
have any new or
worsening mental
problems while
taking FYCOMPA.

What is FYCOMPA
(perampanel)?

FYCOMPA is a
prescription
medicine used alone
or with other
medicines to treat
partial-onset
seizures with or
without secondarily
generalized seizures
in people with
epilepsy aged 4 and
older and with other
medicines to treat
primary generalized
tonic-clonic
seizures in people
with epilepsy aged
12 and older.

Like other antiepileptic
drugs, FYCOMPA may cause
suicidal thoughts or
actions in a very small
number of people, about
1 in 500. Call your
healthcare provider
right away if you have
any of these symptoms,
especially if they are
new, worse, or worry
you:

thoughts about suicide
or dying; new or worse
depression; feeling
agitated or restless;
trouble sleeping
(insomnia); acting
aggressive; being angry,
or violent; an extreme
increase in activity and
talking (mania); attempt
to commit suicide; new
or worse anxiety; panic
attacks; new or worse
irritability; acting on
dangerous impulses;
other unusual changes in
behavior or mood.
Suicidal thoughts or
actions can be caused by
things other than
medicines. If you have
suicidal thoughts or
actions, your healthcare
provider may check for
other causes.

Pay attention to any
changes especially
sudden changes in mood,
behaviors, thoughts, or
feelings and keep all
follow-up visits with
your healthcare provider
as scheduled. Call your
healthcare provider
between visits as
needed, especially if
you are worried about
symptoms.

Do not stop FYCOMPA
without first talking
with your healthcare
provider.

Stopping suddenly can
cause serious problems
and can cause you to
have seizures more
often.

Before taking FYCOMPA,
tell your healthcare
provider about all of
your medical conditions,
including if you:

have or have had
depression, mood
problems, aggressive or
hostile behavior (for
example, homicidal
behavior), suicidal
thoughts or behavior, or
other psychiatric
problems; have liver or
kidney problems; drink
alcohol; have abused
prescription medicines,
street drugs, or alcohol
in the past; are
pregnant or plan to
become pregnant. It is
not known if FYCOMPA
will harm your unborn
baby. If you become
pregnant while taking
FYCOMPA, talk to your
healthcare provider
about registering with
the North American
Antiepileptic Drug
Pregnancy Registry
(1-888-233-2334)(1-888-233-2334); are breastfeeding or
plan to breastfeed. Talk
to your healthcare
provider about the best
way to feed your baby if
you take FYCOMPA and to
decide if you will take
FYCOMPA or breastfeed.
You should not do both.

Tell your healthcare
provider about all the
medicines you take,

including prescription
and over-the-counter
medicines, vitamins, and
herbal supplements.
Taking FYCOMPA with
certain other medicines
can cause side effects
or reduce either drug’s
benefit. These medicines
include: birth control,
carbamazepine,
phenytoin,
oxcarbazepine, rifampin,
and St. John’s Wort.

What should I avoid
while taking FYCOMPA?

Do not drive, operate
heavy machinery, or do
other dangerous
activities until you
know how FYCOMPA affects
you. FYCOMPA may make
you dizzy, sleepy, or
tired. Do not drink
alcohol or take other
medicines that make you
sleepy or dizzy until
you talk to your
healthcare provider.
FYCOMPA taken with
alcohol or medicines
that cause sleepiness or
dizziness may make your
sleepiness or dizziness
worse. FYCOMPA when
taken with alcohol may
also make your mood
worse, increase anger,
confusion, and
depression.

FYCOMPA may cause other
serious side effects,
including: Dizziness,
vertigo (sense of
spinning), and problems
walking normally.

You may have problems
walking normally if you
are unsteady because you
feel dizzy. These
symptoms can increase
when your dose of
FYCOMPA is increased.
Your risk of feeling
dizzy and having
problems walking
normally may be higher
if you are
elderly;
Sleepiness and
tiredness; Increased
risk of
falls.
Taking FYCOMPA can
increase your chance of
falling. These falls can
cause serious injuries.
Your risk of falling may
be higher if you are
elderly;
A serious allergic
reaction that may
affect your skin or
other parts of your
body such as your
liver, kidneys,
heart, or blood
cells.
This allergic reaction
can be life-threatening
and can cause death.
Call your healthcare
provider right away if
you have: a skin rash,
hives; fever or swollen
glands that do not go
away; swelling of your
face; shortness of
breath; swelling of the
legs; yellowing of the
skin or whites of the
eyes; or dark urine

The most common side
effects of FYCOMPA
include:

dizziness; sleepiness;
tiredness; irritability;
falls; nausea and
vomiting; weight gain;
vertigo (sense of
spinning); problems
walking normally;
problems with muscle
coordination; headache;
bruising; abdominal
pain; anxiety

FYCOMPA is a controlled
substance (CIII) because
it can be abused or lead
to drug dependence. Keep
FYCOMPA in a safe place
to protect it from theft
and never give it to
anyone else because it
may harm them. Selling
or giving away FYCOMPA
is against the law.

You are encouraged to
report negative side
effects of prescription
drugs to the FDA. Visit
www.fda.gov/medwatch
or call
1-800-FDA-10881-800-FDA-1088.

media/media/
Prescribing
Information
and
Medication Guide
for FYCOMPA.

Stories from
others with
epilepsy.

Your browser does not support the video
tag.

[H3] Meet Leslie
Leslie shares how FYCOMPA helped her and her
husband discover a life full of adventure.

Your browser does not support the video
tag.

[H3]
Meet Nick
Nick talks about getting diagnosed with epilepsy
at a young age and how his mother learned how
to help manage his epilepsy.

Your browser does not support the video
tag.

[H3]
Meet Shantia
Shantia discusses her first seizure and journey
to finding the right treatment for her epilepsy.

[H2]
Stay tuned
for more
updates

FYCOMPA
maybe
able
to
help

Learn
how

Find
out
if
yourseizures
are
under
control

Take
the
quiz

What is FYCOMPA
(perampanel)?

FYCOMPA is a
prescription medicine
used alone or with other
medicines to treat
partial-onset seizures
with or without
secondarily generalized
seizures in people with
epilepsy aged 4 and
older and with other
medicines to treat
primary generalized
tonic-clonic seizures in
people with epilepsy
aged 12 and older.

IMPORTANT SAFETY
INFORMATION

FYCOMPA may cause
mental (psychiatric)
problems, including:

new or worse
aggressive behavior
(including homicidal
behavior),
hostility, anger,
anxiety, or
irritability; being
suspicious or
distrustful
(believing things
that are not true);
seeing objects or
hearing things that
are not there;
confusion;
difficulty with
memory; other
unusual or extreme
changes in behavior
or mood. Tell your
healthcare provider
right away if you
have any new or
worsening mental
problems while
taking FYCOMPA.

What is FYCOMPA
(perampanel)?

FYCOMPA is a
prescription
medicine used alone
or with other
medicines to treat
partial-onset
seizures with or
without secondarily
generalized seizures
in people with
epilepsy aged 4 and
older and with other
medicines to treat
primary generalized
tonic-clonic
seizures in people
with epilepsy aged
12 and older.

Like other antiepileptic
drugs, FYCOMPA may cause
suicidal thoughts or
actions in a very small
number of people, about
1 in 500. Call your
healthcare provider
right away if you have
any of these symptoms,
especially if they are
new, worse, or worry
you:

thoughts about suicide
or dying; new or worse
depression; feeling
agitated or restless;
trouble sleeping
(insomnia); acting
aggressive; being angry,
or violent; an extreme
increase in activity and
talking (mania); attempt
to commit suicide; new
or worse anxiety; panic
attacks; new or worse
irritability; acting on
dangerous impulses;
other unusual changes in
behavior or mood.
Suicidal thoughts or
actions can be caused by
things other than
medicines. If you have
suicidal thoughts or
actions, your healthcare
provider may check for
other causes.

Pay attention to any
changes especially
sudden changes in mood,
behaviors, thoughts, or
feelings and keep all
follow-up visits with
your healthcare provider
as scheduled. Call your
healthcare provider
between visits as
needed, especially if
you are worried about
symptoms.

Do not stop FYCOMPA
without first talking
with your healthcare
provider.

Stopping suddenly can
cause serious problems
and can cause you to
have seizures more
often.

Before taking FYCOMPA,
tell your healthcare
provider about all of
your medical conditions,
including if you:

have or have had
depression, mood
problems, aggressive or
hostile behavior (for
example, homicidal
behavior), suicidal
thoughts or behavior, or
other psychiatric
problems; have liver or
kidney problems; drink
alcohol; have abused
prescription medicines,
street drugs, or alcohol
in the past; are
pregnant or plan to
become pregnant. It is
not known if FYCOMPA
will harm your unborn
baby. If you become
pregnant while taking
FYCOMPA, talk to your
healthcare provider
about registering with
the North American
Antiepileptic Drug
Pregnancy Registry
(1-888-233-2334)(1-888-233-2334); are breastfeeding or
plan to breastfeed. Talk
to your healthcare
provider about the best
way to feed your baby if
you take FYCOMPA and to
decide if you will take
FYCOMPA or breastfeed.
You should not do both.

Tell your healthcare
provider about all the
medicines you take,

including prescription
and over-the-counter
medicines, vitamins, and
herbal supplements.
Taking FYCOMPA with
certain other medicines
can cause side effects
or reduce either drug’s
benefit. These medicines
include: birth control,
carbamazepine,
phenytoin,
oxcarbazepine, rifampin,
and St. John’s Wort.

What should I avoid
while taking FYCOMPA?

Do not drive, operate
heavy machinery, or do
other dangerous
activities until you
know how FYCOMPA affects
you. FYCOMPA may make
you dizzy, sleepy, or
tired. Do not drink
alcohol or take other
medicines that make you
sleepy or dizzy until
you talk to your
healthcare provider.
FYCOMPA taken with
alcohol or medicines
that cause sleepiness or
dizziness may make your
sleepiness or dizziness
worse. FYCOMPA when
taken with alcohol may
also make your mood
worse, increase anger,
confusion, and
depression.

FYCOMPA may cause other
serious side effects,
including: Dizziness,
vertigo (sense of
spinning), and problems
walking normally.

You may have problems
walking normally if you
are unsteady because you
feel dizzy. These
symptoms can increase
when your dose of
FYCOMPA is increased.
Your risk of feeling
dizzy and having
problems walking
normally may be higher
if you are
elderly;
Sleepiness and
tiredness; Increased
risk of
falls.
Taking FYCOMPA can
increase your chance of
falling. These falls can
cause serious injuries.
Your risk of falling may
be higher if you are
elderly;
A serious allergic
reaction that may
affect your skin or
other parts of your
body such as your
liver, kidneys,
heart, or blood
cells.
This allergic reaction
can be life-threatening
and can cause death.
Call your healthcare
provider right away if
you have: a skin rash,
hives; fever or swollen
glands that do not go
away; swelling of your
face; shortness of
breath; swelling of the
legs; yellowing of the
skin or whites of the
eyes; or dark urine

The most common side
effects of FYCOMPA
include:

dizziness; sleepiness;
tiredness; irritability;
falls; nausea and
vomiting; weight gain;
vertigo (sense of
spinning); problems
walking normally;
problems with muscle
coordination; headache;
bruising; abdominal
pain; anxiety

FYCOMPA is a controlled
substance (CIII) because
it can be abused or lead
to drug dependence. Keep
FYCOMPA in a safe place
to protect it from theft
and never give it to
anyone else because it
may harm them. Selling
or giving away FYCOMPA
is against the law.

You are encouraged to
report negative side
effects of prescription
drugs to the FDA. Visit
www.fda.gov/medwatch
or call
1-800-FDA-10881-800-FDA-1088.

Prescribing
Information
and
Medication Guide
for FYCOMPA.