Information Density: INVOKANA (Johnson & Johnson) – Signal Evidence & AI Readability

[H1] If you have type 2 diabetes—your kidneys need attention!
LEARN MORE
[H2] INVOKANA® is the first type 2 diabetes medication proven in a landmark clinical study to lower the risk of:
End-stage kidney disease (ESKD)Worsening of kidney functionCardiovascular deathHospitalization for heart failureIn adults with type 2 diabetes and diabetic kidney disease (nephropathy) with a certain amount of protein in the urine.
[H3] Johnson & Johnson wants to help you explore cost support options for INVOKANA®.
We’d like to help! Learn if you’re eligible for savings options, and get support. EXPLORE SAVINGS OPTIONS
[H2] INVOKANA® also:
Lowers the risk of heart attack, stroke, or cardiovascular death in adults with type 2 diabetes and established cardiovascular disease.Lowers blood sugar (A1C) in adults and children aged 10 years and older with type 2 diabetes, along with diet and exercise.LEARN MORE
[IMG: 2 red kidney caricatures holding hands]
[H2] Type 2 diabetes can really hurt your kidneys—and you may not even know it’s happening.
Our kidneys work hard to do some very important things for us. But unfortunately, type 2 diabetes can cause diabetic kidney disease, a serious situation that can have no early symptoms and can lead to dialysis, transplant, hospitalization for heart failure, and even death. What should you do? What’s an eGFR number—and why is it important to know it? Learn the answers to these important questions and more here.GET THE FACTS

[H1] Get Savings and Support
[H2] Get Support for your Johnson & Johnson medicine
Once you and your doctor have decided INVOKANA®, INVOKAMET® XR (canagliflozin/metformin HCl extended-release tablets), or INVOKAMET® (canagliflozin/metformin HCl)  is right for you, J&J withMe will help you find the resources you may need to get started and stay on track.
[IMG: Savings co-pay card]
[H3] Already registered?
Log in to your J&J withMe Patient Account, where you can manage your Savings Program benefits and submit Savings Program requests.You will need to log in with your e-mail address and the password you created when you registered.Paying for INVOKANA®, INVOKAMET® XR (canagliflozin/metformin HCl extended-release), and INVOKAMET® (canagliflozin/metformin HCl)At Johnson & Johnson, we don't want cost to get in the way of treatment you need. We can help you explore options to lower your out-of-pocket cost for your J&J medicine. No matter what type of insurance you have—or even if you don't have insurance—J&J withMe can help find programs that may help you pay for INVOKANA®, INVOKAMET® XR, and INVOKAMET®.If you have commercial or private health insurance and need help paying for your J&J medicine, the J&J withMe Savings Program may be able to help. For more information, visit Invokana.JNJwithMeSavings.com.Register NowIf you use commercial or private health insurance to pay for your medicine:
[H3] J&J withMe Savings Program
Eligible commercial or private patients pay $0 per month for INVOKANA®, INVOKAMET® XR, and INVOKAMET®. Maximum program benefits per calendar year shall apply. Terms expire at the end of each calendar year. Offer subject to change or end without notice. Restrictions, including monthly maximums, may apply. Not valid for patients using Medicare, Medicaid, or other government-funded programs to pay for their medications. Participate without sharing your income information. See program requirements.To get a J&J withMe Savings Program cardCreate an online account and enroll at Account.JNJwithMe.com or call a J&J withMe Care Coordinator at 866-228-3546, Monday–Friday, 8:00 AM–8:00 PM ET. When you register, you’ll receive a J&J withMe Savings Program card. Download and print the card and present the card at your pharmacy along with a valid prescription. Your eligibility to use this card is dependent upon meeting the program requirements each time you present the card when filling your prescription.If you are using a government-funded healthcare program to pay for INVOKANA®, INVOKAMET®,  and INVOKAMET® XR or have no insurance coverage and need help paying for your medicine:J&J withMe can provide information about other resources that may be able to help with your out-of-pocket medicine costs for your J&J medicine. Visit JNJwithMe.com or call a J&J withMe Care Coordinator at 877-468-6526 or for more information about affordability programs and independent foundations* that may have funding available.*Independent co-pay assistance foundations have their own rules for eligibility, which are subject to change. We cannot guarantee a foundation will help you. We can only refer you to foundations that support your disease state. This information is provided as a resource for you. We do not endorse any particular foundation.If your insurance plan doesn't approve INVOKANA®, INVOKAMET® XR, or INVOKAMET®:Sometimes, your insurance company may deny coverage of a medicine your doctor has prescribed for you. For example, your insurance plan might not cover a medicine because it is not on their approved prescription drug list (Formulary) or they may have other rules or policies that cause a denial of coverage. If this happens, you and your doctor can request that your insurance company cover the medicine through an exception process. You can ask your doctor to complete a Letter of Medical Necessity or Letter of Exception depending on the reason the medicine isn't covered for you. Samples of both letter types are available for your doctor to download at JNJwithMe.com.
[H2] Ongoing Support
Need help? Call J&J withMe at 877-468-6526, Monday–Friday, 8 AM to 8 PM ET. Multilingual phone support is available.The support and resources provided by J&J withMe are not intended to provide medical advice, replace a treatment plan you receive from your doctor or nurse, or serve as a reason for you to start or stay on treatment.Additional Affordability Support from Johnson & JohnsonPatient assistance is available if you are uninsured or have commercial, employer-sponsored, or government coverage that does not fully meet your needs. You may be eligible to receive your medicine from J&J at no cost for up to one year if you meet the eligibility and income requirements for the Johnson & Johnson Patient Assistance Program. See terms and conditions at PatientAssistanceInfo.com

[IMG: A red kidney caricature sitting at an office desk]
[IMG: A red kidney caricature sitting at an office desk]
[H1] INVOKANA® has been proven to help:
[IMG: Blue pair of kidneys icon]
In adults with type 2 diabetes and diabetic kidney disease (nephropathy) with a certain amount of protein in the urine
[H2] Lower the risks of end-stage kidney disease and hospitalization for heart failure.
[IMG: Purple heart icon]
In adults with established cardiovascular disease and type 2 diabetes
[H2] Lower the risks of heart attack, stroke, and cardiovascular death.
[IMG: Magenta sugar cube icon]
In adults and children aged 10 years and older with type 2 diabetes, along with diet and exercise
[H2] Significantly lower blood sugar (A1C).
INVOKANA® is not for people with type 1 diabetes. It may increase their risk of diabetic ketoacidosis (increased ketones in blood or urine). INVOKANA® is not used to lower blood sugar (glucose) in adults with type 2 diabetes with severe kidney problems.INVOKANA® is the first type 2 diabetes medicine approved to lower the risks of end-stage kidney disease (ESKD), worsening of kidney function, cardiovascular death, and hospitalization for heart failure. In fact, it’s the first type 2 diabetes medicine in almost 20 years approved to treat diabetic kidney disease in adults with type 2 diabetes.In most clinical studies, INVOKANA® has helped people with type 2 diabetes reach the ADA-recommended blood sugar (A1C) goal of less than 7%.In adults with type 2 diabetes, along with diet and exercise
[H3] Although it’s not for weight loss, INVOKANA® may help you lose weight—on average 2–3%.
Results may vary by dose and when used alone or with certain other diabetes medications. Before starting any type of exercise, please check with your doctor. In adults with type 2 diabetes, along with diet and exercise
[H3] Although it’s not a blood pressure medication, INVOKANA® may help you see lower systolic blood pressure—on average 3–5 mmHg.
Results may vary by dose and when used alone or with metformin, sitagliptin, or insulin.The safety and efficacy of INVOKANA® has been shown in 16 completed clinical trials with more than 20,000 patients.The most common side effects with INVOKANA® include genital yeast infections, urinary tract infections, and changes in urination.
[H3] Talk to your doctor about type 2 diabetes and diabetic kidney disease
Diabetic kidney disease is a serious complication associated with type 2 diabetes. At your next appointment, use the guide below to ask questions about diabetic kidney disease and what you can do to help your kidneys.DOWNLOAD
[IMG: A red kidney caricature holding a blue arrow sign pointing right]
[H3] Want to learn more?
Read on about how INVOKANA works.

[IMG: 2 red kidney caricatures sitting on a sofa]
[IMG: 2 red kidney caricatures sitting on a sofa]
[H1] Meet your wonderful kidneys
[H2] Our kidneys are superheroes in our bodies. They do so much for us! Every 30 minutes, they filter all of our blood to clear out waste and toxins, they help control blood pressure, they produce substances that keep our bodies healthy and regulated, and more.
In people with type 2 diabetes, there is increased pressure in the glomerulus (the filtering part of the kidneys). Over time this pressure can damage the kidneys—causing a condition called diabetic kidney disease, or DKD. About 1 in 3 people with type 2 diabetes have DKD. Certain population groups, such as African Americans, Hispanic Americans, and American Indians, have a higher risk of developing kidney failure from type 2 diabetes than Caucasian Americans.
[H2] Your kidneys are at risk—and they’re not good at getting your attention.
[H3] DKD progresses slowly and silently—often showing no symptoms until later stages.
Diabetic kidney disease progresses slowly and silently—often showing no symptoms until later stages. In other words, your kidneys may not warn you that they’re in danger until things have advanced. People with DKD often don’t know they have it. In the meantime, damage could be building up over time, and the kidneys may eventually fail. People with kidney failure need dialysis (regular time on a machine that cleans the blood), or a kidney transplant; otherwise, serious complications including death may occur.
[H2] What do the stages of DKD look like?
There are five stages of diabetic kidney disease, ranging from very mild damage all the way to kidney failure. Blood or urine tests are often used to diagnose diabetic kidney disease. Sometimes, additional tests are needed to determine how well your kidneys are functioning and if there has been any damage.The stage of DKD you have is determined by your doctor measuring your estimated glomerular filtration rate (eGFR)—or how well your kidneys filter waste from your blood. This test checks how much blood passes through the tiny filters in the kidneys (glomeruli) that remove waste from the blood each minute.
[H2] Stage One
At stage one of DKD, you have mild kidney damage—such as protein in your urine or physical kidney damage—and an eGFR of 90 or higher. At this point, your kidneys are still working well, but—because DKD is progressive—your doctor might have you implement some lifestyle changes to slow down possible kidney damage. These may include:Control your blood sugarControl your blood pressureEat a healthy dietDo not smoke or use tobaccoBe active 30 minutes a day, 5 days a weekStay at a healthy weightAsk your doctor if there are medicines you can take to help your kidneys and whether you need to see a kidney doctor (nephrologist), even if you already have a general doctor.
[H2] Stage Two
At this stage, you have kidney damage, but the amount of protein in your urine or your physical kidney damage is higher, and you may have an eGFR between 60 and 89. This means your kidneys are still healthy and working well, but you may want to talk to your doctor about implementing treatment options and lifestyle changes to help slow the progression of DKD.
[H2] Stage Three
At this stage there is further damage to the kidneys, your eGFR is between 30 and 59, and you still may not have any symptoms. If you do have symptoms, they could be:Swelling in your hands and feetBack painUrinating (peeing) more or less than normalYou are also more prone to complications at this stage—like high blood pressure, a low number of red blood cells (anemia), and bone disease. These complications can be treated with a lower-protein diet to minimize waste products in your blood and medicines that:Lower pressure in the glomerulus (the filtering part of the kidneys)Manage your blood pressureLower cholesterol levelsTreat anemiaRelieve swellingProtect your bonesAt this point, it is important to implement any lifestyle changes recommended by your doctor. Other ways you can help slow the progression of kidney disease at this stage are by getting a treatment plan from a nephrologist, meeting with a dietitian to help improve your eating habits, and—if you have type 2 diabetes—talking to your doctor about ways you can continue to manage it.
[H2] Stage Four
This stage of DKD is the last stage before kidney failure—and, unfortunately, the stage when most people learn they have DKD. Stage four means that not only do you have an eGFR between 15 and 30, but also your kidneys might be moderately or severely damaged—leading to the symptoms and complications listed in stage three. You should seek out regular appointments with a nephrologist, follow a diet plan put together by a registered dietitian, and continue to take any medications as prescribed by a doctor.
[H2] Stage Five
At this point, your kidneys have either failed or are getting close to failing. You may have an eGFR of less than 15 and may be experiencing the symptoms of kidney failure, which can include:ItchingMuscle crampsFeeling sick and throwing upNot feeling hungrySwelling in your hands and feetBack painUrinating (peeing) more or less than normalTrouble breathingTrouble sleepingYour doctor will discuss your treatment options including dialysis or even a kidney transplant.
[H2] Speak up for your kidneys. Your doctor—and INVOKANA®—could help.
That’s a lot of scary news about your kidneys—but don’t get discouraged! It's important to know what your risks are so you can make smart decisions for your health. Using a simple blood test, your doctor can detect kidney disease early—and INVOKANA® can be prescribed to help.
[H2] When diabetic kidney disease is detected early, there’s a better chance of slowing the progression.
So, if you have type 2 diabetes, speak up on behalf of your amazing kidneys. Make an appointment to talk about your kidneys—and INVOKANA®—today!To learn more about kidney disease and access other resources, check out the National Kidney Foundation and the American Kidney Fund.
[IMG: A red kidney caricature holding a blue arrow sign pointing right]
[H3] Want to learn more about type 2 diabetes?
Read on about type 2 diabetes.