Information Density: Timeline – Signal Evidence & AI Readability

#1Doctor RecommendedUrolithin A Brand
[IMG: Timeline Mitopure Skincare]
[IMG: Timeline Mitopure Skincare]
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[H1] No other supplement does this.
Award-winning clinically proven Urolithin A products.Shop nowTime to give your cells new life with high-performance products powered by Mitopure, our powerful ingredient that unlocks a precise dose of the rare Urolithin A molecule and promotes healthy aging.Time to give your cells new life with high-performance products powered by Mitopure, our powerful ingredient that unlocks a precise dose of the rare Urolithin A molecule and promotes healthy aging.Discover our science
[H2] 18
Years of researchIn collaboration with the Swiss Federal Institute of Technology de Lausanne (EPFL)
[H2] 25
Human clinical trialsCompleted and ongoing gold-standard clinical trials involving over 2000 participants
[H2] 500⁺
Studies on Urolithin AScientists have extensively explored the effectiveness of Urolithin A on health
[H2] 80
PatentsOur proprietary ingredient Mitopure® is protected under 80 patentsDiscover our scienceGold-standard Clinical TrialsGold-standard Clinical TrialsRenewalStrengthEnergyBioavailabilityMitochondrial renewal increases by +39% after 16 weeks over placebo*See study detailsPublished in
[IMG: Cell Reports Medicine]
PlaceboSupplementsHear from our scientistsabout how Mitopure® renews cellsWatch nowCompare us to otherSupplementsUrolithin A
[H2] The Ultimate Longevity Powerhouse
Comparison criteriaDirectly activates mitophagyTargets a root cause of age-related cellular energy declineBenefits without exerciseComplete human clinical trialsComparison criteriaNAD+CoQ10CreatineSpermidineDirectly activates mitophagyPartialTargets a root cause of age-related cellular energy declinePartialPartialPartialBenefits without exerciseComplete human clinical trialsLimitedLimited
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#1Doctor RecommendedUrolithin A Brand
[H2] Mitopure Gummies
4.8 stars(1461) reviewsA strawberry-flavored dose of cellular energyBestseller
[IMG: Mitopure Softgels]
[IMG: Mitopure Softgels]
#1Doctor RecommendedUrolithin A Brand
[H2] Mitopure Softgels
4.5 stars(4228) reviewsThe simplest form of Mitopure
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#1Doctor RecommendedUrolithin A Brand
[H2] Mitopure Powder
4.5 stars(1094) reviewsA tasty addition to your health routineShop all
[H2] Loved by our community
[H3] Revitalized mind and body
Amanda KVerified buyer@chloezakhour
[H3] Game changer for your energy and health
Ines KVerified buyer@colleenchambersofficial
[H3] A lifesaver
Catherine JVerified buyer@zachsale
[H3] Superior product!
SYLVIA MVerified buyer@ugcbrittbeauty
[H3] Excellent supplement
Debra KVerified buyer@healthyhabitsbytiffanie
[H3] Increased Strength and Energy
Margaret MVerified buyer@itsanotherb
[H3] My stamina is returning....
Carol BVerified buyer@andrewc.ugcRead all reviews
[H2] Find out why the experts trust Urolithin A from Timeline
[IMG: Dr. Mark Hyman, MD]
[IMG: Dr. Mark Hyman, MD]
[IMG: Dr. Gabrielle Lyon]
[IMG: Dr. Johan Auwerx MD, PhD]
[IMG: Eric Verdin, MD]
“This is a supplement I use myself everyday to be as healthy as I can, for as long as I can.”
[H3] Dr. Mark Hyman, MD
Functional Medicine Physician, 15x New York Times Bestselling Author

[IMG: Mitopure Urolithin A Gummies]
[H1] Mitopure® is the supplement that changes how cells age.
[IMG: Man smiling]
Your body is made of trillions of cells.Your health, now and as you age, depends on their health.Mitochondria are the batteries that make your cells work.These cellular batteries start wearing out in your 30s.Insufficient energy supplyProduction of harmful moleculesReduced cellular health
[H2] Weak mitochondria affect every system in your body.
[IMG: Woman stretching]
BrainBrainThe human brain uses about 25% of the human body’s metabolic energy and is particularly sensitive to the aging process. Scientists are looking into the contributions of mitochondria in brain health with preliminary studies suggesting they could be key players in brain.Scientific ResearchGrimm, A. and Eckert, A. (2017), Brain aging and neurodegeneration: from a mitochondrial point of view. J. Neurochem., 143: 418-431. https://doi.org/10.1111/jnc.14037Fang et al. (2019). Mitophagy inhibits amyloid-β and tau pathology and reverses cognitive deficits in models of Alzheimer's disease. Nature neuroscience, 22(3), 401–412. https://doi.org/10.1038/s41593-018-0332-9SkinSkinSkin requires a lot of energy provided by mitochondria. As you age, dysfunctional mitochondria lead to reduced energy production, cellular decline and signs of aging like sagginess, dullness, wrinkles and weakened skin barrier. Enhanced mitochondrial function can improve skin cellular energy, youthfulness, resilience and overall health.Scientific ResearchMartini H, Passos JF. Cellular senescence: all roads lead to mitochondria. FEBS J. 2023;290(5):1186- 1202.Dodig S, Čepelak I, Pavić I. Hallmarks of senescence and aging. Biochem Med (Zagreb). 2019;29(3):030501. doi:10.11613/BM.2019.030501Sreedhar A, Aguilera-Aguirre L, Singh KK. Mitochondria in skin health, aging, and disease. Cell Death Dis. 2020;11(6):444. Epub 2020/06/11. doi: 10.1038/s41419-020-2649-z. PubMed PMID: 32518230; PubMed Central PMCID: PMCPMC7283348 Biosciences. A.S., L.A.-A., and K.K.S. hold equity in Yuva Biosciences.D’Amico et al. Topical application of Urolithin A slows intrinsic skin aging and protects from UVB-mediated photodamage: Findings from Randomized Clinical Trials. medRxiv 2023.06.16.23291378 (2023). doi:10.1101/2023.06.16.23291378Immune systemImmune systemThe immune system becomes less effective over time. Evidence is rising on the importance of mitochondria in immune aging.
Scientific ResearchDenk, D., Petrocelli, V., Rinsch, C., Greten, F.R, et alExpansion of T memory stem cells with superior anti-tumor immunity by Urolithin A-induced mitophagy. Immunity, 55, Issue 11 (2022). https://doi.org/10.1016/j.immuni.2022.09.014Fang, E.F., Hou, Y., Palikaras, K. et al. Mitophagy inhibits amyloid-β and tau pathology and reverses cognitive deficits in models of Alzheimer’s disease. Nat Neurosci 22, 401–412 (2019). https://doi.org/10.1038/s41593-018-0332-9Jang, J. Y., Blum, A., Liu, J., & Finkel, T. (2018). The role of mitochondria in aging. The Journal of clinical investigation, 128(9), 3662–3670. https://doi.org/10.1172/JCI120842JointsJointsJoint health is key for mobility, independence and quality of life as you age. The cells that keep joints functional progressively decline in function. There is emerging science around the link between mitochondrial health and joint health.Scientific ResearchMao X, Fu P, Wang L and Xiang C (2020) Mitochondria: Potential Targets for Osteoarthritis. Front. Med. 7:581402. doi: 10.3389/fmed.2020.581402Digestive systemDigestive systemThe digestive system is essential to metabolic health, immunity and overall well-being. Mitochondrial health has been associated with improved gut barrier health.Scientific ResearchSingh, R., Chandrashekharappa, S., Bodduluri, S.R. et al. Enhancement of the gut barrier integrity by a microbial metabolite through the Nrf2 pathway. Nat Commun 10, 89 (2019). https://doi.org/10.1038/s41467-018-07859-7Toney, A.M., Fan, R., Xian, Y., Chaidez, V., Ramer-Tait, A.E. and Chung, S. (2019), Urolithin A, a Gut Metabolite, Improves Insulin Sensitivity Through Augmentation of Mitochondrial Function and Biogenesis. Obesity, 27: 612-620. https://doi.org/10.1002/oby.22404Urolithin A Prevents Cisplatin-Induced Nephrotoxicity Melissa Guada, Raghu Ganugula, Manicka Vadhanam and Majeti N.V. Ravi Kumar Journal of Pharmacology and Experimental Therapeutics October 1, 2017, 363 (1) 58-65; DOI: https://doi.org/10.1124/jpet.117.242420Skeletal muscleSkeletal muscleDuring strenuous exercise, the rate of energy use in skeletal muscles can increase more than 100-fold almost instantly. Muscle cells need healthy mitochondria in order to meet this energy demand. Our clinical studies have shown improved muscle strength as a result of improved mitochondrial function.Scientific ResearchAndreux, P.A., van Diemen, M.P.J., Heezen, M.R. et al. Mitochondrial function is impaired in the skeletal muscle of pre-frail elderly. Sci Rep 8, 8548 (2018). https://doi.org/10.1038/s41598-018-26944-xRyu, D., Mouchiroud, L., Andreux, P. et al. Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents. Nat Med 22, 879–888 (2016). https://doi.org/10.1038/nm.4132Luan P, D'Amico D, Andreux PA, Laurila PP, Wohlwend M, Li H, Imamura de Lima T, Place N, Rinsch C, Zanou N, Auwerx J. Urolithin A improves muscle function by inducing mitophagy in muscular dystrophy. Sci Transl Med 13: eabb0319, 2021. doi:10.1126/scitranslmed.abb0319A healthy aging breakthrough
[H2] Mitopure® is clinically proven to revitalize mitochondria.
How Mitopure works
[H3] Renewal
+39%PlaceboIncreases mitochondrial renewal by +39% after 16 weeks over placebo.*See Study Details
[H3] Energy
[IMG: People running on a trail]
Induces a signature of improved mitochondria.*See Study Details
[H3] Strength
+12%Increases muscle strength by up to 12% after 16 weeks.*See Study Details
[H3] Bioavailability
6xMitopure® unlocks 6x more Urolithin A than diet alone.**See Study DetailsDid you know?Only 1 in 3 people can get enough Urolithin A from diet alone.
[H3] Renewal
+39%PlaceboIncreases mitochondrial renewal by +39% after 16 weeks over placebo.*See Study Details
[H3] Energy
[IMG: People running on a trail]
Induces a signature of improved mitochondria.*See Study Details
[H3] Strength
+12%Increases muscle strength by up to 12% after 16 weeks.*See Study Details
[H3] Bioavailability
6xMitopure® unlocks 6x more Urolithin A than diet alone.**See Study DetailsDid you know?Only 1 in 3 people can get enough Urolithin A from diet alone.Did you know?Only 1 in 3 people can get enough Urolithin A from diet alone.How Mitopure works
[IMG: Dr. Mark Hyman, MD]
This is a supplement I use myself everyday to be as healthy as I can, for as long as I can.Dr. Mark Hyman, MDFunctional Medicine Physician, 15x New York Times Bestselling AuthorCompare us to otherSupplementsUrolithin A
[H2] The Ultimate Longevity Powerhouse
Comparison criteriaDirectly activates mitophagyTargets a root cause of age-related cellular energy declineBenefits without exerciseComplete human clinical trialsComparison criteriaNAD+CoQ10CreatineSpermidineDirectly activates mitophagyPartialTargets a root cause of age-related cellular energy declinePartialPartialPartialBenefits without exerciseComplete human clinical trialsLimitedLimitedSwiss Science, Made in U.S.A.Our products meet the highest global standards, with quality and safety verified by NSF
[IMG: NSF]
. Our Urolithin A ingredient has been determined Generally Recognized as Safe (GRAS) by FDA.
[H2] 18⁺
Years of researchIn collaboration with the Swiss Federal Institute of Technology de Lausanne (EPFL)
[H2] 25
Human clinical trialsCompleted and ongoing gold-standard clinical trials on nutrition and skincare involving over 900 participants
[H2] 500⁺
Studies on Urolithin AScientists have extensively explored Urolithin A’s effectiveness on health and patented the bioactive into Mitopure®
[H2] 80
PatentsOur proprietary ingredient Mitopure® is protected under 80 patents
[H2] We aren’t just making supplements
We’re advancing the science of aging, translating cutting-edge biotechnological innovation into solutions for lifelong vitality. Timeline was born out of pioneering research at the École Polytechnique Fédérale de Lausanne (EPFL), where our experts continue to push the boundaries of human healthspan.Our Story
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[H2] Mitopure Gummies
4.8 stars(1463) reviewsA strawberry-flavored dose of cellular energyBestseller
[IMG: Mitopure Softgels]
[IMG: Mitopure Softgels]
[H2] Mitopure Softgels
4.5 stars(4230) reviewsThe simplest form of Mitopure
[IMG: Mitopure Powder]
[IMG: Mitopure Powder]
[H2] Mitopure Powder
4.5 stars(1094) reviewsA tasty addition to your health routine
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[H3] A new way to take Mitopure. Target signs of aging at the source in a new, sugar-free strawberry gummy.
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[H2] Our Mitopure® formats
Our Mitopure® formatsSugar Free
[IMG: Mitopure Gummies (Urolithin A)]
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[IMG: Mitopure Powder (Urolithin A)]
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Mitopure® (Urolithin A)500mg500mg500mgServing size2 gummies2 softgels1 sachetSugarSugar-free (with stevia)Sugar-freeNo added sugarFlavorStrawberryTastelessRaspberryCertificationsFDA GRAS, Clean Label Project Certified, NSF Contents CertifiedFDA GRAS, Clean Label Project Certified, NSF Certified for SportFDA GRAS, Clean Label Project Certified, NSF Certified for SportShop nowShop nowShop nowCompare us to otherSupplementsUrolithin A
[H2] The Ultimate Longevity Powerhouse
Comparison criteriaDirectly activates mitophagyTargets a root cause of age-related cellular energy declineBenefits without exerciseComplete human clinical trialsComparison criteriaNAD+CoQ10CreatineSpermidineDirectly activates mitophagyPartialTargets a root cause of age-related cellular energy declinePartialPartialPartialBenefits without exerciseComplete human clinical trialsLimitedLimited
[H2] Loved by our community
[H3] Revitalized mind and body
Amanda KVerified buyer@chloezakhour
[H3] Game changer for your energy and health
Ines KVerified buyer@colleenchambersofficial
[H3] A lifesaver
Catherine JVerified buyer@zachsale
[H3] Superior product!
SYLVIA MVerified buyer@ugcbrittbeauty
[H3] Excellent supplement
Debra KVerified buyer@healthyhabitsbytiffanie
[H3] Increased Strength and Energy
Margaret MVerified buyer@itsanotherb
[H3] My stamina is returning....
Carol BVerified buyer@andrewc.ugcRead all reviews
[H3] Still unsure? Try our samples
Shop Samples
[IMG: Mitopure Gummies Sample]
[IMG: Mitopure Gummies Sample]
#1Doctor RecommendedUrolithin A Brand
[H2] Mitopure Gummies Sample
4.8 stars(1463) reviews3 servings of sugar-free gummies with 500 mg Mitopure
[IMG: Mitopure Softgels Sample]
[IMG: Mitopure Softgels Sample]
#1Doctor RecommendedUrolithin A Brand
[H2] Mitopure Softgels Sample
4.5 stars(4230) reviews3 servings of vegan softgels with 500mg of Mitopure
[IMG: Mitopure Powder Sample]
[IMG: Mitopure Powder Sample]
#1Doctor RecommendedUrolithin A Brand
[H2] Mitopure Powder Sample
4.5 stars(1094) reviews3 stickpacks of our berry-flavored powder with 500mg of MitopureShop Samples

[IMG: Analog Clock]
[H1] Aging never stops. But how does it start?
They're the engines that keep your organs functioning optimally.Mitophagy is the crucial pathway that removes dysfunctional mitochondria.But in your 30s mitophagy starts to slow down.Old, damaged mitochondria build up, draining cellular energy.You get weaker, feel fatigued, and your skin visibly ages.There is a nutrient that stimulates mitophagy.90% of your body's energy comes from mitochondria.It's a rare postbiotic molecule called Urolithin A.It's a rare postbiotic molecule called Urolithin A.Urolithin A is formed in the gut through digestion of foods like pomegranates.But few people have the right gut bacteria to produce it.Polyphenol‑rich dietMicrobiomeUrolithin A
[H3] Mitopure® is clinically proven to revitalize mitochondria, targeting signs of aging at the foundation.
Discover all benefitsEven those who do would have to eat 50 pomegranates a day to get enough.There's an easier way. Mitopure® is the original Urolithin A supplement.
[H2] Mitopure Transformation
Hour08Day02Day30Day60Day120Day365
[IMG: Cells]
[H2] Hour 08
[H3] Urolithin A gets absorbed
You've just begun taking Mitopure and it's already springing into action. Urolithin A levels peak in your bloodstream, targeting key organs like your muscles.
[IMG: Mitophagy]
[H2] Day 02
[H3] Cellular recycling is activated
Mitopure® stimulates mitophagy, a potent recycling and cleansing mechanism that rejuvenates the mitochondria, the energy factories in your cells.
[IMG: Mitochondrial biogenesis]
[H2] Day 30
[H3] New healthy mitochondria
One month in, your cells are transforming. Damaged mitochondria are removed and healthier ones are produced in a process called mitochondrial biogenesis.
[IMG: Woman boxing]
[H2] Day 60
[H3] Enhanced cellular renewal
With our mitochondria recharged and renewed, the cells throughout your body are starting to function optimally.
[IMG: Muscle fibers]
[H2] Day 120
[H3] Increased muscle strength*
Four months in, your muscle cells are reenergized and you’re getting stronger — even without a change in your exercise routine.
[IMG: Healthy cell]
[H2] Day 365
[H3] Optimal cellular health
You’re supporting your health at its foundation and the benefits continue to build. Keep taking Mitopure to experience system-wide wellbeing and improve your healthspan.
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[H3] Change how your cells age. Explore our science-backed longevity solutions.
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